Published on by Global CAD Awards

Innovative Research Award

Peter V. Dubovskii
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russia

Peter V. Dubovskii
Affiliation Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry
Country Russia
Scopus ID 7004283478
Documents 53
Citations 1,129
h-index 22
Subject Area Design of novel antibiotics
Event Global Cad Awards

Peter V. Dubovskii is a researcher affiliated with the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry in Moscow, Russia. Publicly available scholarly records associate his research with biomolecular structure, membrane-active peptides, cobra cytotoxins, antimicrobial activity, and molecular approaches to understanding peptide–membrane interactions. His documented work includes studies of antibacterial activity and the structural determinants that influence membrane activity. [1][2]

Abstract

Peter V. Dubovskii’s documented research profile is centered on the structural and biophysical investigation of membrane-active peptides and toxins, with particular attention to their interactions with lipid membranes and their antibacterial properties. His published work has examined cobra cytotoxins, spider antimicrobial peptides, cardiotoxins, and molecular determinants of membrane disruption. These studies provide experimentally grounded insight into how molecular structure, charge distribution, hydrophobicity, and conformational features can influence biological activity. .[1] [2]

Keywords

Antimicrobial peptides; novel antibiotics; cobra cytotoxins; membrane-active peptides; molecular modeling; membrane interactions; peptide structure; antibacterial activity; bioorganic chemistry; biomolecular structure.

Introduction

Antimicrobial peptides and membrane-active proteins are studied as potential sources of mechanistic knowledge for developing new approaches to bacterial control. Their biological activity can depend on several structural parameters, including molecular charge, hydrophobicity, peptide conformation, and the organization of membrane-interacting regions. Research attributed to Dubovskii and collaborators has investigated these relationships using biochemical, structural, spectroscopic, and modeling approaches. [1][3] [5]

Research Profile

Available scholarly sources identify Peter V. Dubovskii as a researcher at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry. His academic background includes physics and bioorganic chemistry, while his research record encompasses biomolecular modeling and experimental investigation of biologically active peptides and toxins.

  • Membrane interactions of biologically active peptides and proteins.
  • Structural investigation of cobra cytotoxins and cardiotoxins.
  • Antibacterial properties of venom-derived molecules.
  • Molecular modeling and structure–activity relationships.
  • Investigation of antimicrobial peptides, including spider-derived peptides.

Research Contributions

The research record associated with Dubovskii includes several contributions to the understanding of peptide–membrane interactions. Early work examined the interaction of P-type cardiotoxin with phospholipid membranes, contributing structural and biophysical information about membrane-active toxins.

Publications

The supplied recognition profile reports 53 documents. The following selected publications are included as bibliographic examples supported by publicly available scholarly records; they are not intended to represent the complete publication list.

  1. Dubovskii, P. V., et al. Antibacterial activity of cardiotoxin-like basic polypeptide from cobra venom. Bioorganic & Medicinal Chemistry Letters, 2020, 30(3), 126890.
  2. Dubovskii, P. V., et al. Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop. Toxins, 2023, 15(1), 6.
  3. Dubovskii, P. V., et al. Spatial Structure and Activity Mechanism of a Novel Spider Antimicrobial Peptide. Biochemistry, 2006, 45(35), 10759–10767.
  4. Dubovskii, P. V., et al. Three-Dimensional Structure/Hydrophobicity of Latarcins Specifies Their Mode of Membrane Activity. Biochemistry, 2008, 47(11).
  5. Dubovskii, P. V., et al. Interaction of the P-type cardiotoxin with phospholipid membranes. European Journal of Biochemistry, 2003, 270(9), 2038–2046

Research Impact

The supplied profile records 1,129 citations and an h-index of 22 across 53 documents. These figures are presented as provided for the recognition profile and may change as bibliographic databases update their records. They should therefore be interpreted as a time-dependent bibliometric snapshot rather than a permanent measure of research significance.

Independently verifiable publication records demonstrate sustained engagement with questions concerning membrane-active toxins and antimicrobial peptides. For example, his work on cobra cytotoxins has addressed antibacterial activity, membrane disruption, and the structural determinants of toxin–membrane interactions.[1][2] [5]

Award Suitability

For the purposes of the Innovative Research Award recognition profile associated with Global CAD Awards, the supplied subject area is design of novel antibiotics. The documented research record is relevant to antimicrobial research through its investigation of antibacterial activity and membrane-active peptides, particularly venom-derived molecules. [1] [5]

Conclusion

Peter V. Dubovskii’s documented scholarly work encompasses structural biology, bioorganic chemistry, molecular modeling, membrane biophysics, and the study of antimicrobial and membrane-active peptides. His publications provide evidence of sustained investigation into the molecular mechanisms underlying toxin and peptide interactions with membranes, including antibacterial effects.[1][2] [5] The supplied bibliometric profile reports 53 documents, 1,129 citations, and an h-index of 22, while the specific award profile identifies design of novel antibiotics as the relevant subject area.

References

  1. Dubovskii PV, Ignatova AA, Feofanov AV, Utkin YN, Efremov RG. Antibacterial activity of cardiotoxin-like basic polypeptide from cobra venom. Bioorganic & Medicinal Chemistry Letters. 2020;30(3):126890.
    https://doi.org/10.1016/j.bmcl.2019.126890
  2. Dubovskii PV, et al. Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop. Toxins. 2023;15(1):6.
    https://doi.org/10.3390/toxins15010006
  3. Dubovskii PV, Konshina AG, Efremov RG. Cobra cardiotoxins: membrane interactions and pharmacological potential. Current Medicinal Chemistry. 2014;21(3):270–287.
    https://doi.org/10.2174/09298673113206660315
  4. Dubovskii PV, et al. Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins. Toxins. 2024;16(6):262.
    https://doi.org/10.3390/toxins16060262
  5. Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS. Spatial Structure and Activity Mechanism of a Novel Spider Antimicrobial Peptide. Biochemistry. 2006;45(35):10759–10767.
    https://doi.org/10.1021/bi060635w
Peter V. Dubovskii | Design of novel antibiotics | Innovative Research Award

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